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Bioengineered nCAR/miR-34a-5p does not cause any hepatic, renal or cardiac toxicity in mouse models in vivo. The blood chemistry profiles, including ALT, AST, TB, BUN, Cr and cTnI, were all within the normal ranges, indicating a good biocompatibility of bioengineered nCAR/miR-34a-5p in mouse models in vivo.
