Fig. 1.

Overview of experimental study design.

Participants will reside in our laboratory facilities during which energy intake, energy expenditure and sleep will be monitored and controlled. Urine, blood and fecal samples will be collected using standard methods to assess BPA, hepatic glucose production ([6,6-²H] glucose infusion), skeletal muscle insulin sensitivity (euglycemic hyperinsulinemic clamp technique), and the fecal microbiome. HGP, hepatic glucose production; Clamp, skeletal muscle insulin sensitivity.