Table 4.
Comparison of operative and postoperative parameters between neoadjuvant chemotherapy and surgery-first groups, n (%)
| Variable |
All patients |
P value |
Matched patients |
P value | ||
| NAC and surgery (n = 36) | Surgery first (n = 108) | NAC and surgery (n = 36) | Surgery first (n = 36) | |||
| Type of surgery | 0.109 | 0.430 | ||||
| Total gastrectomy | 24 (66.7) | 87 (80.6) | 24 (66.7) | 28 (77.8) | ||
| Subtotal gastrectomy | 12 (33.3) | 21 (19.4) | 12 (33.3) | 8 (22.2) | ||
| Combined resection | 1.000 | 1.000 | ||||
| Yes | 1 (2.8) | 4 (3.7) | 1 (2.8) | 2 (5.6) | ||
| No | 35 (97.2) | 104 (96.3) | 35 (97.2) | 34 (94.4) | ||
| Resection | 1.000 | 1.000 | ||||
| R0 | 32 (88.9) | 96 (88.9) | 32 (88.9) | 31 (86.1) | ||
| R1/R2 | 4 (11.1) | 12 (11.1) | 4 (11.1) | 5 (13.9) | ||
| Operation time (min) | 196 ± 54 | 197 ± 56 | 0.961 | 196 ± 54 | 190 ± 49 | 0.600 |
| Blood loss (mL) | 144 ± 139 | 127 ± 140 | 0.527 | 144 ± 139 | 129 ± 122 | 0.628 |
| Blood transfusion | 0.495 | 1.000 | ||||
| Yes | 32 (88.9) | 100 (92.6) | 4 (11.1) | 4 (11.1) | ||
| No | 4 (11.1) | 8 (7.4) | 32 (88.9) | 32 (88.9) | ||
| Morbidity | 0.563 | 0.478 | ||||
| Yes | 3 (8.3) | 14 (13.0) | 3 (8.3) | 6 (16.7) | ||
| No | 33 (91.7) | 94 (87.0) | 33 (91.7) | 30 (83.3) | ||
| Postoperative hospital stay (d) | 13.3 ± 4.9 | 13.9 ± 13.2 | 0.821 | 13.3 ± 4.9 | 14.2 ± 14.0 | 0.743 |
| Borrmann type | 0.082 | 0.450 | ||||
| I | 3 (8.3) | 10 (9.3) | 3 (8.3) | 1 (2.8) | ||
| II | 10 (27.8) | 11 (10.2) | 10 (27.8) | 6 (16.7) | ||
| III | 17 (47.2) | 69 (63.9) | 17 (47.2) | 22 (61.1) | ||
| IV | 6 (16.7) | 18 (16.7) | 6 (16.7) | 7 (19.4) | ||
| Tumor size (cm) | 5.9 ± 3.3 | 5.9 ± 2.9 | 0.995 | 5.9 ± 3.2 | 6.0 ± 3.5 | 0.927 |
| Neural invasion | 0.700 | 0.474 | ||||
| Yes | 18 (50.0) | 74 (68.5) | 17 (47.2) | 13 (36.1) | ||
| No | 18 (50.0) | 34 (31.5) | 19 (52.8) | 23 (63.9) | ||
| Lymphovascular invasion | 0.848 | 0.341 | ||||
| Yes | 17 (47.2) | 55 (50.9) | 18 (50.0) | 23 (63.9) | ||
| No | 19 (52.8) | 53 (49.1) | 18 (50.0) | 13 (36.1) | ||
| Pathological tumor classification | 0.001 | 0.039 | ||||
| (y)pT0-1 | 5 (13.9) | 0 (0) | 5 (13.9) | 0 (0) | ||
| (y)pT2 | 0 (0) | 1 (0.9) | 0 (0) | 1 (2.8) | ||
| (y)pT3 | 9 (25.0) | 40 (37.0) | 9 (25.0) | 15 (41.7) | ||
| (y)pT4a/4b | 22 (61.1) | 67 (62.0) | 22 (61.1) | 20 (55.6) | ||
| Pathologic nodal classification | 0.09 | 0.671 | ||||
| (y)pN0 | 12 (34.3) | 15 (13.9) | 12 (34.3) | 8 (22.2) | ||
| (y)pN1 | 3 (8.6) | 12 (11.1) | 3 (8.6) | 3 (8.3) | ||
| (y)pN2 | 7 (20.0) | 28 (25.9) | 7 (20.0) | 7 (19.4) | ||
| (y)pN3 | 13 (37.1) | 53 (49.1) | 13 (37.1) | 18 (50.0) | ||
| Adjuvant chemotherapy | 1.000 | 0.396 | ||||
| Yes | 26 (72.2) | 77 (71.3) | 26 (72.2) | 30 (83.3) | ||
| No | 10 (27.8) | 31 (28.7) | 10 (27.8) | 6 (16.7) | ||
NAC: Neoadjuvant chemotherapy.