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. 2020 Feb 28;26(8):789–803. doi: 10.3748/wjg.v26.i8.789

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Prognosis-related differentially expressed genes validated in four additional cohorts and construction of the prognostic gene signature. A: Venn diagram showing the results of genes validated in four cohorts; B: Circos plot showing overlapping genes between the four cohorts. Purple curves link identical genes while blue curves link genes that belong to the same enriched ontology term; C: LASSO coefficient profiles of 52 genes validated in four cohorts; D: Distribution of risk scores; E: Patients’ survival time and status. The black dotted line indicates the optimum cutoff dividing patients into low- and high-risk groups; (F) Kaplan-Meier curves for low- and high-risk groups; G: Heat map of ten key genes in the genes signature; H: Time-dependent receiver operating characteristic curves for comparing prediction accuracy among the ten-gene-based signature and clinicopathological features.