Table 3.
Mean change in neurocognitive test scores from baseline to month 6 (intent-to-treat-analysis set).
| Neurocognitive test | Baseline mean (SD) | Endpoint mean (SD) | Change from baseline mean (SD) |
|---|---|---|---|
| Speed of processing | |||
| Phonetic Verbal Fluency–Total Score (z-score) | n = 217 −2.3 (1.84) |
n = 189 −1.8 (1.80) |
n = 177 0.4 (1.12) |
| Semantic Verbal Fluency–Total Score (z-score) | n = 214 −1.6 (1.17) |
n = 188 −1.5 (1.09) |
n = 173 0.2 (0.91) |
| Trail Making Test- Part A–Total Time (z-score) | n = 55 −0.9 (2.72) |
n = 55 −1.2 (5.29) |
n = 38 0.0 (6.69) |
| Child Color Trails Test 1–Total Time (t-score) | n = 213 27.6 (12.95) |
n = 213 31.7 (14.30) |
n = 180 4.7 (14.62) |
| Child Color Trails Test 2–Total Time (t-score) | n = 213 29.1 (12.31) |
n = 208 31.8 (13.42) |
n = 177 2.5 (13.53) |
| Motor speed | |||
| Finger Tapping Test–Dominant Hand (z-score) | n = 309 −1.1 (1.91) |
n = 311 −0.9 (1.92) |
n = 271 0.2 (1.44) |
| Finger Tapping Test–Non-Dominant Hand (z-score) | n = 309 −0.7 (2.14) |
n = 312 −0.4 (2.08) |
n = 271 0.3 (1.69) |
| Attention/working memory | |||
| WISC-IV/WAIS-III Digit Span (scaled-score) | n = 317 7.6 (3.50) |
n = 312 8.3 (3.52) |
n = 282 0.8 (2.71) |
| WISC-IV/WAIS-III Digit Symbol Coding (scaled-score) | n = 298 5.5 (3.77) |
n = 296 6.0 (3.53) |
n = 260 0.7 (2.75) |
| Visual learning and memory | |||
| Rey Complex Figure Test–Total Score (z-score) | n = 307 −1.4 (2.90) |
n = 306 −1.4 (2.93) |
n = 271 0.0 (2.18) |
| Rey Complex Figure Test–Immediate Score (z-score) | n = 303 −1.4 (1.77) |
n = 301 −0.5 (1.68) |
n = 265 0.8 (1.33) |
| Rey Complex Figure Test–Delayed Score (z-score) | n = 300 −1.5 (1.74) |
n = 296 −0.7 (1.72) |
n = 259 0.8 (1.35) |
| Rey Complex Figure Test–Recognition Score (z-score) | n = 294 −1.6 (1.68) |
n = 291 −1.4 (1.79) |
n = 257 0.3 (1.61) |
| Verbal learning and memory | |||
| CVLT-C/CVLT-II - Total Trials (t-score) | n = 46 35.1 (13.41) |
n = 36 44.5 (15.41) |
n = 30 7.2 (12.70) |
| CVLT-C/CVLT-II-Trial B (z-score) | n = 46 −1.1 (1.22) |
n = 35 −0.9 (1.05) |
n = 29 0.1 (1.36) |
| CVLT-C/CVLT II–Short Delay Free Recall (z-score) | n = 46 −1.3 (1.46) |
n = 35 −0.7 (1.23) |
n = 29 0.2 (1.21) |
| CVLT-C/CVLT-II–Long Delay Free Recall (z-score) | n = 44 −1.2 (1.55) |
n = 34 −0.4 (1.30) |
n = 28 0.5 (1.11) |
| WRAML Story Memory–Total Score (scaled-score) | n = 39 7.6 (3.98) |
n = 35 9.0 (3.92) |
n = 27 1.3 (2.33) |
| WRAML Story Delay–Total Score (scaled score) | n = 39 7.6 (4.22) |
n = 35 9.2 (4.30) |
n = 27 1.5 (3.40) |
| WRAML Story Recognition–Total Score (scaled score) | n = 41 8.2 (3.96) |
n = 34 9.2 (3.69) |
n = 27 1.0 (3.06) |
| Executive functioning (reasoning and problem solving) | |||
| WCST–Total Errors (t-score) | n = 234 50.7 (14.73) |
n = 171 57.9 (14.76) |
n = 190 5.9 (12.38) |
| WCST–Perseverative Errors (scaled score) | n = 234 53.5 (17.32) |
n = 260 60.9 (16.99) |
n = 190 6.0 (15.61) |
| WCST–non-Perseverative Errors: (scaled score) | n = 234 50.7 (13.38) |
n = 259 56.5 (12.04) |
n = 189 4.9 (10.81) |
| Trail Making Test-Part B–Time (z-score) | n = 49 −1.1 (2.64) |
n = 53 −1.6 (2.85) |
n = 33 0.5 (2.57) |
| Social cognition | |||
| Theory of Mind Test–Total Score (raw-score) | n = 305 43.9 (11.70) |
n = 292 48.6 (11.41) |
n = 269 4.7 (8.23) |
WAIS III- Wechsler Adult Intelligence Scale; Under age 16; WISC IV- Wechsler Intelligence Scale for Children; CVLT, California Verbal Learning Test; WCST, Wisconsin Card Sort Test; WRAML, Wide Range Assessment of Memory and Learning; Z scores have a mean = 0, and SD = 1, T-scores have a mean = 50, and SD = 10, and scaled scores have a mean = 10, and SD = 3.