Table 3.
Histological scores of WD fed WT and LDLR−/− mice
| Mouse Genotype and Diet | Macrovesicular Steatosis | Microvesicular Steatosis | Hepatocellular Hypertrophy | NAFLD Score | Inflammation | Fibrosis |
|---|---|---|---|---|---|---|
| WT WD | 0 | 3 | 1 | 4 | 1 | absent |
| WT WD | 1 | 3 | 1 | 5 | 0 | absent |
| WT WD | 0 | 0 | 0 | 0 | 0 | absent |
| WT WD | 1 | 3 | 3 | 7 | 1 | mild |
| WT WD | 1 | 3 | 2 | 6 | 0 | absent |
| WT WD | 0 | 2 | 1 | 3 | 0 | mild |
| LDLR−/− WD | 1 | 2 | 1 | 4 | 0 | mild |
| LDLR−/− WD | 2 | 2 | 1 | 5 | 1 | mild |
| LDLR−/− WD | 1 | 2 | 1 | 4 | 3 | moderate |
| LDLR−/− WD | 2 | 3 | 2 | 7 | 2 | mild |
| LDLR−/− WD | 2 | 3 | 2 | 7 | 3 | mild |
| LDLR−/− WD | 3 | 2 | 2 | 7 | 3 | moderate |
| LDLR−/− WD | 2 | 2 | 1 | 5 | 3 | mild |
NAFLD, nonalcoholic fatty liver disease; WT, wild-type; LDLR−/−, low-density lipoprotein receptor-deficient; WD, Western diet.