. 2019 Nov 25;318(2):G288–G297. doi: 10.1152/ajpgi.00011.2019

Table 4.

Fold changes in Na⁺ channel and transporter mRNA expression in the porcine colon

	Segment of Porcine Colon
	Proximal			Apex			Distal
Ion Channel	Control	B. hyo	B. hamp	Control	B. hyo	B. hamp	Control	B. hyo	B. hamp
NHE1	2.15 ± 1.42^a	0.27 ± 0.10^b	0.33 ± 0.08^a	1.02 ± 0.11^a	0.44 ± 0.11^b	0.47 ± 0.10^b	1.76 ± 0.49^a	0.51 ± 0.24^b	0.38 ± 0.08^b
NHE2	1.30 ± 0.47^a	0.38 ± 0.12^b	0.31 ± 0.06^b	1.04 ± 0.13^a	0.08 ± 0.01^b	0.18 ± 0.09^b	1.42 ± 0.38^a	0.26 ± 0.03^b	0.32 ± 0.11^b
NHE3	1.16 ± 0.30^a	0.11 ± 0.02^b	0.24 ± 0.04^b	1.17 ± 0.36^a	0.36 ± 0.11^b	0.28 ± 0.11^b	1.33 ± 0.44^a	0.29 ± 0.10^b	0.14 ± 0.04^b
ENaC-α	1.49 ± 0.61^a	0.76 ± 0.29^a	0.38 ± 0.13^a	1.05 ± 0.17^a	0.09 ± 0.04^b	0.03 ± 0.01^b	1.59 ± 0.67^a	0.44 ± 0.10^a	0.17 ± 0.05^b
ENaC-β	1.45 ± 0.76^a	0.26 ± 0.06^a	2.32 ± 0.98^a	1.21 ± 0.31^a	0.47 ± 0.13^a	1.42 ± 0.28^a	1.61 ± 0.65^a	1.44 ± 0.18^a	2.66 ± 0.88^a
ATP1A1	1.36 ± 0.48^a	0.21 ± 0.03^b	0.31 ± 0.06^b	1.27 ± 0.45^a	0.57 ± 0.16^a	0.47 ± 0.09^a	1.48 ± 0.44^a	0.85 ± 0.12^a	0.60 ± 0.10^a

Data are means ± SE of fold difference in gene expression measured by quantitative RT-PCR; n = 6 ctrl, n = 6 B. hyodysenteriae, and n = 6 B. hampsonii. Fold changes in Na⁺ channel and transporter mRNA expression in 3 segments (proximal, apex, and distal) of the colon in B. hyodysenteriae, and B. hampsonii-diseased pigs compared with control are shown. NHE, Na⁺/H⁺ exchanger; ENaC, epithelial sodium channel; ATP1A1, Na-K-ATPase α₁-subunit. Significantly different values are marked in bold.

^{^a,b}

Each gene marked with a different superscript letter differs by at least P < 0.05 compared with control in each segment.