Fig. 2.

Time course of mitochondrial function and content changes after different muscle stressors. Oxygen consumption measurements of permeabilized tibialis anterior (TA) or extensor digitorum longus (EDL) muscle fibers and mitochondrial enzyme assays (citrate synthase, CS, and succinate dehydrogenase, SDH) immediately, 6 h, 1, 3, and 7 days after fatiguing protocol (n = 12) (A), eccentric contraction-induced injury (n = 20) (B), and traumatic freeze injury (n = 28) (C). Dashed line represents average contralateral control limb and shaded gray regions are ± SD of control limb. Stressed limb data are presented as means ± SD. Differences in mitochondrial function and content at different time points after muscle stress were analyzed by RM ANOVA with the repeated measures being the injured vs. uninjured contralateral control limb and the other factor being time. *Significantly different from uninjured. †Significantly different from immediate injured.