Fig. 5.

Muscle torque, mitochondrial function, and mitochondrial content before and after injury in Unc-51 like autophagy activity kinase 1 (Ulk1) muscle-specific knockout (MKO) mice. A: comparison of Ulk1 MKO (n = 10) and littermate (LM; n = 10) dorsiflexion muscle torque before (uninjured) and 14 days after freeze injury. B: oxygen consumption of permeabilized tibialis anterior (TA) muscle in injured and contralateral uninjured limbs 14 days after freeze injury. C and D: citrate synthase (CS) activity (C) and succinate dehydrogenase (SDH) activity (D) in TA muscles of LM (n = 5) and Ulk1 MKO (n = 5) mice in both injured and contralateral control limbs. Differences were analyzed by two-way RM ANOVA with the repeated measures being the injured vs. uninjured contralateral control limb and the other factor being genotype. Main effects are reported.