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Age-dependent shortening of calcium handling. A: calcium transients recorded from the epicardial surface of excised, intact hearts [250-ms pacing cycle lengths (PCL)]. B and C: prolonged calcium transient durations were observed in younger hearts at 30 and 80% repolarization (CaD30 and CaD80). Data were binned into the following age groups: postnatal day (PND) 0–3, PND 4–7, PND 8–14, and adult (2–3 mo). Data are means ± SD; n ≥ 5 animals per age. *P < 0.05.
