Fig. 5.
Greater vasoconstrictor sensitivity in lungs from chronic hypoxia (CH) vs. control neonates is PKC dependent: changes in total (A), arterial (B), and venous (C) resistance (mmHg·mL−1·kg·min) to 9,11-dideoxy-9α,11α-methanoepoxy prostaglandin F2α (U-46619) in lungs from control and CH neonates. Inset in C uses a smaller y-axis scale to allow better visualization of differences between groups. Experiments were conducted in the continued presence of Nω-nitro-l-arginine (300 μM) with or without the PKC inhibitor Ro 31-8220 (10 μM). Values are means ± SE; n = 5 rats for control vehicle, n = 6 rats for CH vehicle, n = 5 rats for control + Ro 31-8220, n = 4 rats for CH + Ro 31-8220. *P < 0.05 vs. control, #P < 0.05 vs. vehicle, analyzed by 2-way ANOVA at each U-46619 concentration ([U-46619]) with a Student-Newman-Keuls post hoc test.