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Administration of adenovirus expressing dimethylarginine dimethylaminohydrolase-1 (Ad-h-DDAH-1) reduces albuminuria in diabetic mice. Urine was collected from mice and analyzed for the urine albumin-to-creatinine ratio. Data are presented as means ± SE; n = 10–13 mice/group. *P < 0.005 compared with normal; #P < 0.05 compared with adenovirus expressing green fluorescent protein (Ad-GFP)-treated diabetic mice.
