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Administration of adenovirus expressing dimethylarginine dimethylaminohydrolase-1 (Ad-h-DDAH-1) reduces kidney pathology in diabetic mice. Paraffin-embedded mouse kidney sections were subjected to periodic acid-Schiff staining. Scale bar = 50 µm (×40) and 20 µm (×100). Data are presented as means ± SE; n = 8–11 mice/group. *P < 0.005 compared with normal; #P < 0.005 compared with adenovirus expressing green fluorescent protein (Ad-GFP)-treated diabetic mice.
