Fig. 7.
Administration of adenovirus expressing dimethylarginine dimethylaminohydrolase-1 (Ad-h-DDAH-1) reduces inflammatory cytokines and fibrotic markers in diabetic mice. RT-PCR was performed on RNA extracted from kidney and analyzed for the indicated genes using indicated Taqman primers. Threshold cycle (Ct) values were normalized to 18S rRNA values and then compared with normal mice. Data are presented as means ± SE; n = 6–7 mice/group. *P < 0.01 and **P < 0.001 compared with normal; #P < 0.05 compared with adenovirus expressing green fluorescent protein (Ad-GFP)-treated diabetic mice.