Fig. 1.

Hematoxylin and eosin-stained sections of mouse lungs. Insets: ×2 magnification of peribronchial regions. Ten days of intranasal house dust mite (HDM) exposure led to peribronchial and perivascular leukocyte infiltration (middle) compared with intranasal phosphate buffered saline (PBS) vehicle controls (left). Coadministration of either oral whole ginger extract (A, right; 40 mg/kg twice daily) or intraperitoneal (ip) 6-shogaol (B, right; 50 µL of 6.6 mM solution twice daily) attenuated the HDM-mediated inflammation. Scale bar, 500 µm.