Fig. 4.
Budesonide (Bud) augments forskolin-induced bronchodilation of human small airways. Budesonide (10 μM) was given simultaneously with forskolin (Fsk; 10−12 to 10−5 M) and bronchodilation was assessed. Concentration-response curves to Fsk (A) were plotted. Maximal bronchodilation at 10−5 M Fsk (B, Fsk vs. Fsk + budesonide at maximum of 10−5 M Fsk, 83.7 ± 8.5% vs. 110.1 ± 10.6%) and area under the curve (C, FSK vs. FSK + budesonide, 151.9 ± 11.8 vs. 232.3 ± 29.1) were significantly increased in the presence of budesonide. Data are representative of n = 5 donors. *P < 0.05 compared with control/Fsk.