Study	Reason for exclusion
Baker 2002	Allocation: randomised Participants: acutely agitated inpatients with schizophrenia spectrum or bipolar 1 disorder Interventions: 2 different drugs given 'as required', not the 'as required' regimen versus no 'as required' regimen
Foster 1997	Allocation: randomised Participants: patients in emergency room, judged to be in imminent danger to self or needing 4‐point restraints Intervention: 2 different drugs given 'as required', not the 'as required' regimen versus no 'as required' regimen
Hovens 2005	Allocation: randomised Participants: patients with an acute exacerbation of schizophrenia or other psychotic disorder Interventions: 2 different drugs given for the treatment of schizophrenia plus 'as required' medication, not 'as required' regimen versus no 'as required' regimen
Huttunen 1996	Allocation: randomised Participants: people with chronic schizophrenia Interventions: depot medication regimens (haloperidol) versus oral antipsychotic medication, not 'as required' regimen versus no 'as required' regimen
Kinon 2001	Allocation: randomised Participants: newly admitted inpatients with a diagnosis of schizophrenia spectrum disorders Intervention: 2 different drugs given for the treatment of acute schizophrenia (olanzapine plus lorazepam) plus 'as required' medication, not 'as required' regimen versus no 'as required' regimen
Kinon 2008	Allocation: randomised Participants: acutely unwell patients with a diagnosis of schizophrenia, schizophreniform or schizoaffective disorders and needing inpatient treatment Intervention: 2 different drugs given for the treatment of acute schizophrenia (olanzapine versus aripiprazole) plus 'as required' medication but not 'as required' regimen versus no 'as required' regimen
Kramer 1978	Allocation: randomised Participants: people with acute schizophrenia Interventions: 2 different drugs for treatment of acute schizophrenia (loxapine versus thioridazine), not 'as required' regimen
Lesem 2001	Allocation: randomised Participants: people with schizophrenia or schizophrenia‐like illnesses Interventions: comparison of different doses of same drug (ziprasidone, 2 mg versus 10 mg), not 'as required' regimen
Maoz 2000	Allocation: randomised Participants: newly admitted inpatients with a diagnosis of schizophrenia or schizophreniform disorder Interventions: comparison of an adjuvant drug (active and placebo arms) to an antipsychotic (haloperidol‐propranolol). 'As required' medication allowed in both arms of trial but not 'as required' regimen versus no 'as required' regimen
Neborsky 1984	Allocation: randomised Participants: people with schizophrenia or psychotic illnesses Interventions: comparison between behaviour and plasma levels of haloperidol, not 'as required' regimen
Potkin 2006	Allocation: randomised Participants: acutely unwell patients with a diagnosis of schizophrenia or schizoaffective disorder and needing inpatient treatment Interventions: comparing 2 drugs for the treatment of acute exacerbation of schizophrenia (risperidone, quetiapine and placebo) but not 'as required' regimen
Slotnick 1971	Allocation: randomised Participants: acutely agitated psychiatric patients Interventions: comparing 2 different drugs (haloperidol and chlorpromazine) not 'as required' regimen
Stotsky 1977	Allocation: randomised Participants: acutely agitated, psychotic patients Interventions: comparing 2 different drugs (haloperidol and thiothixene) not 'as required' regimen
Zhang 2013	Allocation: randomised Participants: acutely unwell patients with schizophrenia Interventions: comparison of 2 different drugs (intramuscular ziprasidone versus haloperidol) given 'as required' but not 'as required' regimen versus no 'as required' regimen