Platt 1985.
Methods | Quasi‐randomisation using sequential numbers (even/odd). | |
Participants | 642 women with high‐risk pregnancies, ie post‐term (41%), IUGR (13%), diabetes (12%), decreased fetal movements (7%), hypertension (12%), previous stillbirth (3%). 279 women were randomised to a BPP and 373 to the control group. Mean gestational age 39 weeks. | |
Interventions | BPP versus CTG (non‐stress test). Experimental group: BPP twice weekly. Control group: CTG and ultrasound measurement of the maximum pool depth twice weekly. If monitoring was normal, labour was induced at 43 weeks. Abnormal monitoring was an indication for induction of labour as soon as possible. | |
Outcomes | Perinatal death (> 500 gr, < 28 day of life). Intrapartum fetal distress (persistent late decelerations, bradycardia or serial fetal scalp sampling with pH < 7.20, or both. Apgar < 7 after 5 minutes Birthweight below 10th centile. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | High risk | C ‐ Inadequate |
AFI: amniotic fluid index BPP: biophysical profile CTG: cardiotocography FBM: fetal breathing movements FM: fetal movements FT: fetal tone IUGR: intrauterine growth retardation MBPP: modified biophysical profile