Table 1.
Selected markers in mouse macrophage subsets.
| M1 macrophages | M2 macrophages | MMe ATMs | Kupffer cells | Liver MoMFs |
|---|---|---|---|---|
| CD80 | Mannose receptor (CD206) | ABCA1 | F4/80high | CD11bhigh |
| CD11c | CD301 | PLIN2 | CD11bint | F4/80int/high |
| Inducible NO synthase | IL-4 receptor (CD124) | LAMP2 | Tim4+ | Ly6C+/- |
| TNF-α | Arginase 1 | NPC1 | Clec4f+ | CCR2+ |
| S100A8/A9 (calprotectin) | CD68+ | CX3CR1+/- |
Expression of the macrophage polarization markers is context-dependent and these should ideally be used in combination. MMe ATMs: metabolically activated adipose tissue macrophages; MoMFs, monocyte-derived macrophages.