TABLE 3.
Stability of GDC-0084 in human plasma and whole blood
| Matrix | Storage condition | 0.5 ng/mL |
160 ng/mL |
|||
|---|---|---|---|---|---|---|
| Mean (%CV) | %Change | Mean (%CV) | %Change | |||
| Human plasma | 4°C, 24 h | 0.502 (0.5) | −3.5 | 166 (2.8) | 7.8 | |
| RT, 24 h | 0.516 (0.9) | −0.2 | 164 (2.3) | 7.9 | ||
| −80°C, 355 days | 0.547 (0.4) | 6.4 | 163 (4.3) | 4.7 | ||
| Three F/T cycles | 0.489 (1.2) | −4.9 | 144 (2.2) | −7.1 | ||
| Extracts, 4°C, 24 h | 0.499 (1.6) | −2.2 | 160 (1.6) | 2.6 | ||
| Extracts, 4°C, 48 h | 0.506 (1.8) | −0.8 | 157 (1.6) | 0.6 | ||
| Human whole blood | 4°C, 0 h | 0.318 (2.4) | aND | 108 (1.1) | aND | |
| 4°C, 1 h | 0.315 (1.0) | −1.2 | 107 (0.5) | −1.5 | ||
| 4°C, 24 h | 0.369 (4.6) | 15.8 | 124 (0.8) | 14.5 | ||
| Human CSF | 4°C, 24 h | 0.469 (1.5) | −7.6 | 153 (3.0) | −1.5 | |
| RT, 24 h | 0.479 (1.8) | −5.5 | 154 (2.0) | −0.2 | ||
| −80°C, 7 days | 0.499 (4.4) | 0.27 | 155 (0.7) | 0.0 | ||
| Three F/T cycles | 0.506 (7.4) | 3.1 | 156 (2.1) | 1.1 | ||
| Extracts, 4°C, 24 h | 0.501 (4.4) | 0.6 | 154 (1.5) | −0.9 | ||
| Extracts, 4°C, 96 h | 0.458 (3.7) | −8.0 | 153 (1.0) | −1.5 | ||
a
ND, not determined.