. Author manuscript; available in PMC: 2020 Sep 11.

Published in final edited form as: Eur J Prev Cardiol. 2019 May 13;27(13):1412–1422. doi: 10.1177/2047487319850717

Table 4.

Results from Cox proportional hazard models estimating the association between PTSD and OAU and incident CVD among patients without depression (n=1,631)

	Fully adjusted
	HR (95%CI)

OAU within PTSD strata
No PTSD: OAU vs. no OAU	2.00 (1.33–3.02)
PTSD: OAU vs. no OAU	1.94 (1.16–3.24)
OAU*PTSD
None	1.00
PTSD only	0.86 (0.62–1.20)
OAU only	2.00 (1.33–3.02)
PTSD+OAU	1.67 (1.01–2.78)
	Estimate (95% CI)
Multiplicative interaction
Ratio of OAU HR’s within PTSD strata	0.97 (0.51–1.84)
Additive interaction
RERI	−0.19 (−1.27, 0.89)

Note: CVD=cardiovascular disease; OAU=opioid analgesic use; HR=hazard ratio; CI=confidence interval; RERI=relative excess risk due to interaction; fully adjusted model controlled for all covariates shown in Table 2.

Significant estimates are bolded