| Methods |
RCT |
| Participants |
European multicentre trial of children 2 to 8 years old |
| Interventions |
Azithromycin 10 mg/kg daily for 3 days
versus
amoxil‐clavulanate 3 times daily for 10 days |
| Outcomes |
Absence or improvement of signs and symptoms at 10 to 12 days after study entry |
| Notes |
— |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Blinding (performance bias and detection bias)
Treatment failure at 1 month or less |
High risk |
|
| Incomplete outcome data (attrition bias)
Treatment failure at 1 month or less |
Low risk |
|
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
High risk |
Potential bias in that in the short course, azithromycin patients were placed on different antibiotics if failing, whereas for co‐amoxil they stayed on co‐amoxil; industry funding |
