| Methods |
Randomised controlled, double‐blind trial |
| Participants |
Children 5 months to 5 years old seen in emergency departments or medical centres in California, North Carolina, US |
| Interventions |
Ceftriaxone 50 mg/kg intramuscularly x 1 dose + placebo 3 times daily for 10 days versus
placebo intramuscularly x 1 dose + amoxicillin 40 mg/kg 3 times daily for 10 days |
| Outcomes |
Absence of symptoms at 10 days and no recurrence at 11 to 30 days and 31 to 90 days after study entry |
| Notes |
— |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
|
| Blinding (performance bias and detection bias)
Treatment failure at 1 month or less |
Low risk |
|
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
Industry funding |
