Table 1. Main characteristics of all the studies included in the systematic review.

Study	Country	Cell Culture	Substance Tested	Parameters Evaluated
Schmidt et al., 2010	Germany	SH-SY5Y, U-937	Amphetamine, Atomoxetine, Methylphenidate	A, C
Schmidt et al., 2010a	Germany	SH-SY5Y, U-937	Amphetamine, Atomoxetine, Methylphenidate	A, B
Schmidt et al., 2010b	Germany	SH-SY5Y	Hypericum perforatum, Pinus radiata, Pinus pinaster	A, B
Nam et al., 2014	Korea	SH-SY5Y	YY162*	A
Feio-Azevedo et al., 2017	Portugal	SH-SY5Y	Amphetamine e metabolites**	A, C
Bartl et al., 2010	Germany	PC12	Methylphenidate	A, B, C
Bartl et al., 2014	Switzerland	PC12	Polyunsaturated fatty acids	A, B
Craenenbroeck et al., 2006	Belgium	HEK293rtTA, L929sA, CHO	Pipamperone	A, C
Wakamatsu et al., 2009	Japan	HEK-293	Methylphenidate	A
Ludolph et al., 2010	Germany	TsA201	Atomoxetine	A
Knorle et al., 2012	Germany	JAR	Sideritis scardica	A, B
Suter et al., 2006	Switzerland	Human lymphocytes	Methylphenidate	A
Schwarz et al., 2014	Germany	Lymphoblastoid cell lines	Methylphenidate	A, C
Kittel-Schneider et al., 2016	Germany	Peripheral blood mononuclear cells	Methylphenidate	A
Zhao et al., 2007	China	CHO	Fructus Psoraleae	A
Salviano et al., 2015	Brazil	MDCK	Methylphenidate	A, B

Abbreviations: SH-SY5Y: neuroblastoma SH-SY5Y; U-937: Human monocytic U-927; PC12: Rat pheochromocytoma; HEK293rtTA cells: Human embryonic kidney cells 
expressing the tetracycline transactivator; HEK-293: Human embryonic kidney 293; TsA201: Transformed human embryonic kidney; JAR: Human choriocarcinoma; L929sA: pMx5-HT2AR cells mouse fibrosarcoma; CHO: Chinese hamster ovary; MDCK: Madin-darby canine kidney; *YY162: Mixture of “terpenoid-strengthened Ginkgo biloba” and “ginsenoside Rg3”; **4-hydroxyamphetamine e 4-hydroxynorephedrine; A: culture conditions; B: cell viability; C: gene expression.