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. 2020 Jan 17;11(7):1737–1750. doi: 10.7150/jca.37282

Figure 2.

Figure 2

Biological activities of EBV nuclear antigens (EBNAs) in tumorigenesis. EBNA-1 inhibits antigen presentation by major histocompatibility complex (MHC) class I; EBNA-1 and EBNA-2 activate the expression of LMP-1; EBNA-2 and EBNA-3 interact with C-myc which constitutively activate cyclin D/E leading to unregulated cell proliferation; EBNA-LP can directly activate cyclin D/E and DNA-dependent protein kinase (DNA-PKCs) to promote cell proliferation; EBNA-LP promotes cell survival by interacting with antiapoptotic protein hematopoietic cell-specific protein 1 (HS-1)-associated protein X-1 (HAX-1).