Table 1.
Characteristics of patients with colorectal cancer in Surveillance, Epidemiology, and End Results database (N= 240898) and the international multicenter cohort (N= 1878).
| No. of patients (Percent) | |||
|---|---|---|---|
| SEER database | multicenter cohort | ||
| Race | White | 195333 (81.30%) | NA |
| Black | 25280 (10.52%) | NA | |
| Others | 19654 (8.18%) | NA | |
| Sex | Female | 125827 (52.23%) | 811 (43.23%) |
| Male | 115071 (47.77%) | 1065 (56.77%) | |
| Age (year) | Median (IQR) | 69 (59, 78) | 68 (59, 76) |
| < 60 | 64750 (27%) | 489 (26.26%) | |
| ≥ 60 | 176148 (73%) | 1373 (73.74%) | |
| Tumor size (cm) | Median (IQR) | 4.40 (3.00, 6.00) | 4.50 (3.50, 6.00) |
| ≤ 2 | 24020 (11.18%) | 116 (6.24%) | |
| ≤ 3 | 34309 (15.96%) | 269 (14.47%) | |
| ≤ 5 | 85233 (39.65%) | 823 (44.27%) | |
| > 5 | 71390 (33.21%) | 651 (35.02%) | |
| Tumor site | Proximal colon | 119078 (50.13%) | 604 (32.46%) |
| Distal colon | 79834 (33.61%) | 779 (41.86%) | |
| Rectum | 38642 (16.27%) | 478 (25.69%) | |
| Histology | Adenocarcinoma | 211146 (87.65%) | 1688 (89.83%) |
| Mucinous adenocarcinoma | 25809 (10.71%) | 186 (9.91%) | |
| Signet ring cell carcinoma | 2371 (0.65%) | 4 (0.21%) | |
| Others | 1572 (0.98%) | NA | |
| Grade | Well/Moderately differentiated | 182915(79.67%) | 1327 (71.89%) |
| Poorly or undifferentiated | 46663 (20.33%) | 519 (28.11%) | |
| 7th T stage | T1 | 31113 (14.21%) | 113 (6.09%) |
| T2 | 35099 (16.03%) | 219 (11.81%) | |
| T3 | 124422 (56.82%) | 1246 (67.17%) | |
| T4 | 28372 (12.94%) | 277 (14.93%) | |
| 7th M stage | M0 | 203532 (84.83%) | 1739 (92.60%) |
| M1 | 36400 (15.17%) | 137 (7.29%) | |
| Total no. of nodes retrieved | Median (IQR) | 12 (7, 18) | 10 (5, 14) |
| No. of negative nodes (nN) | Median (IQR) | 10 (6, 16) | 8 (4, 13) |
| No. of positive nodes (pN) | Median (IQR) | 0 (0, 2) | 0 (0, 2) |
| 7th N stage (7th pN) | N0 | 141131 (58.59%) | 1131 (60.22%) |
| N1 | 58625 (24.33%) | 496 (26.41%) | |
| N2 | 41142 (17.07%) | 251 (13.37%) | |
| LODDS | Median (IQR) | -2.51 (-3.3, -1.21) | -2.20 (-3.13, -1.10) |
| LODDS classification | ≤ -2.18 | 141403(58.70%) | 1031 (54.90%) |
| -2.18 - -0.23 | 69821 (28.98%) | 616 (32.80%) | |
| > -0.23 | 29674 (12.32%) | 231 (12.30%) | |
| Follow-up (months) | Median (IQR) | 65 (26, 116) | 48 (21, 75) |
LODDS: log odds of positive lymph nodes; NA: not available; IQR: interquartile range.