Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 17;11(7):1780–1791. doi: 10.7150/jca.38880

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

ASK reduces invasiveness of BCa cell lines. UMUC-3, RT4 and T24 cells (50,000 cells/well) were transfected with Andes-1537 or ASO-C or left untreated (NT) for 48 h. (A) Invasion was determined with Matrigel Transwell Assay. (B) A triplicate analysis showed that ASK induces a drastic and significant reduction of invasiveness in all 3 cell lines. *p<0.05, **p<0.01. (C) UMUC-3 cells transfected as in (A) for 48 h were collected and total lysate was subjected to Western blot analysis of E-cadherin (E-cad), N-cadherin (N-cad) and Matrix Metallopeptidase 11 (MMP), using GAPDH as loading control. ASK induces down regulation of N-cadherin and MMP11.