Figure 2.

OA^nano suppresses the growth of U87 glioma cells. A. U87 glioma cells observed under a fluorescence microscope after 24 h of treatment with DMSO, DMSO-OA and DMSO-OA^nano at 35 μmol/L. bar=100 μm B. Normalized proliferation rate of U87 glioma cells after 24 h of treatment with DMSO, DMSO-OA and DMSO-OA^nano at different concentrations (0, 25, 35, and 45 μmol/L). C. Bioluminescence intensities and areas of the orthotopic glioblastoma xenograft mouse model after treatment by OA^nano and DMSO for 1, 2, and 3 weeks. D. Tumors excised from the survived mice in OA^nano-treated and DMSO groups. E. Reactive fold-change of bioluminescence intensities and areas of the orthotopic glioblastoma xenograft mouse model after treatment by OA^nano and DMSO for 1, 2, and 3 weeks. F. Volume of tumors excised from the survived mice in OA^nano-treated and DMSO groups. G. Caspase-3 positive cells of tumors excised from the survived mice in OA^nano-treated and DMSO groups. H. PCNA positive cells of tumors excised from the survived mice in OA^nano-treated and DMSO groups. I. IHC analysis of Caspase-3 and PCNA in tumors excised from the survived mice in OA^nano-treated and DMSO groups. bar=100 μm. J. H&E staining of tumors excised from the survived mice in OA^nano-treated and DMSO groups. bar=100 μm.