Table 3.

Univariate and Multivariate COX regression analysis for Disease-free Survival and Overall Survival in in young age breast cancer patient group.

Variables	Disease-free Survival				Overall Survival
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR(95%CI)	p value	HR(95%CI)	p value	HR(95%CI)	p value	HR(95%CI)	p value
TNM Staging
I	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
II	1.837(0.950-3.552)	0.071	1.525(0.783-2.972)	0.215	2.057(1.038-4.075)	0.039	1.756(0.881-3.503)	0.110
III	5.631(2.965-10.695)	<0.001	3.999(2.071-7.721)	<0.001	6.263(3.211-12.216)	<0.001	4.241(2.137-8.418)	<0.001
IV	27.496(13.363-56.575)	<0.001	15.965(7.477-34.088)	<0.001	22.081(10.088-48.333)	<0.001	11.317(4.969-25.777)	<0.001
Histological grade
G1	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
G2	2.683 (0.368-19.558)	0.330	1.978 (0.268-14.582)	0.503	2.552(0.349-18.651)	0.356	1.853 (0.251-13.704)	0.546
G3	8.184 (1.142-58.657)	0.036	3.788 (0.518-27.694)	0.189	8.031(1.120-57.578)	0.038	3.955 (0.541-28.938)	0.176
ER status (Negative vs Positive)	0.622(0.441-0.876)	0.007	0.809 (0.566-1.155)	0.244	0.605(0.426-0.861)	0.005	0.784(0.484-1.156)	0.191
PR status (Negative vs Positive)	0.732(0.518-1.036)	0.078	-	-	0.697 (0.489-0.992)	0.045	1.063(0.688-1.642)	0.782
HER-2 status
- or +	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
++	1.018(0.543-1.909)	0.955	0.939 (0.492-1.791)	0.848	0.963 (0.499-1.860)	0.911	0.804 (0.410-1.575)	0.525
+++	1.304(1.034-2.276)	0.033	1.124 (0.749-1.686)	0.573	1.604 (1.077-2.388)	0.020	1.185 (0.785-1.788)	0.420
BMI
Normal weight	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Underweight	1.501(0.970-2.324)	0.068	1.467(0.940-2.291)	0.092	1.557(1.003-2.416)	0.048	1.610(1.028-2.523)	0.037
Overweight	1.676(1.083-2.595)	0.021	1.457(0.931-2.281)	0.099	1.611 (1.024-2.535)	0.039	1.383(0.871-2.196)	0.169

*Statistically significant prognostic factor identified by Univariate/Multivariate analysis