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. 2020 Jan 20;10(6):2453–2462. doi: 10.7150/thno.42981

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Scheme 1 — Metastable-phase manganese sulfide nanotheranostics (MnS@BSA) for tumor pH-responsive traceable hydrogen sulfide (H₂S) gas therapy primed chemodynamic therapy (CDT) of cancer. The MnS@BSA can be degraded in response to the mildly acidic tumor microenvironment, releasing H₂S for gas therapy and Mn²⁺ for magnetic resonance imaging (MRI) and CDT of cancer.