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. 2020 Feb 3;10(6):2832–2848. doi: 10.7150/thno.37119

Figure 1.

Figure 1

Decreased expression of hippocampal PGC-1α in the mice with chronic cerebral hypoperfusion. Wild-type mice were used to establish the VaD model with the chronic cerebral hypoperfusion induced by BCAS. (A) Evaluation of learning ability for BCAS and sham mice using MWM test. Mean escape latency was longer in the BCAS group at the place navigation stage, revealing the impaired spatial learning ability. (B) qRT-PCR analysis showed a significant reduction in the mRNA expressions of mitochondrial antioxidants in the hippocampus of BCAS group compared to the sham group. (C) The mRNA expressions of hippocampal UCPs were also significantly down-regulated in the BCAS group. The levels of hippocampal PGC-1α mRNA (D) and protein (E) expressions were both significantly down-regulated in the BCAS group. (F) Representative images of immunofluorescent staining clearly showed the decreased PGC-1α expressions in the hippocampal CA1 areas of BCAS mice. *p<0.05, **p<0.01 as determined by two-way ANOVA (A) or Mann-Whitney U test (B-E). n = 6 in each group.