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. 2020 Feb 3;10(6):2832–2848. doi: 10.7150/thno.37119

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PGC-1α induces hippocampal BDNF expression after chronic cerebral hypoperfusion. Representative images of brain sections immunostained for BDNF (A, B), and Western blots for BDNF (C) showed that BDNF protein was significantly downregulated in WT+BCAS and PGC-1α^f/f +BCAS groups compared to the sham group. By contrast, BDNF was up-regulated in the nPGC-1α+BCAS group. (D, E) Immunostaining in hippocampal CA1 area showed that there was only a downward trend for the numbers of NeuN-positive neurons in the WT+BCAS and PGC-1α^f/f +BCAS groups compared to the sham and nPGC-1α+BCAS groups. *p<0.05 as determined by one-way ANOVA. n = 5 in each group.