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. 2020 Jan 22;10(6):2553–2570. doi: 10.7150/thno.41120

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Combined predictive role of miR-1275, β-catenin, and NICD in the prognosis and metastasis of LUAD patients. (A) Nomograms were generated according to the multivariate analysis of the SYSUFU cohort to predict 3-year and 5-year OS. (B) Calibration curves indicate the applicability of the nomogram for a 5-year OS. The dashed line indicates the ideal nomogram, and the solid line indicates the actual nomogram. (C) The miR-1275^highβ-catenin^highNICD^high subgroup showed the worst prognosis among the seven subgroups. (D) ROC curves of the prediction models for LUAD metastasis. miR-1275 combined with β-catenin and NICD represented the highest predicted performance for metastasis of the subgroups (AUC=0.879, 95% CI=0.799-0.936, P < 0.001). (E) Proposed molecular mechanism model of miR-1275 in this study.