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. 2020 Feb 3;10(6):2696–2713. doi: 10.7150/thno.41001

Figure 1.

Figure 1

A and B, Overall survival (A) and Disease free survival (B) for VDAC1 expression was calculated from Kidney renal clear cell carcinoma (KIRC) (Gepia.cancer-pku.cn) using the third quartile for the cutoff. C and D, Overall survival (C) and Disease free survival (D) for LGMN expression was calculated from KIRC. E, Tissues lysates (Normal (N), Tumoral (T)) of 19 patients were analyzed by immunoblotting for VDCA1 and LGMN. Hsp-90 was used as a loading control. Group A: high level of VDAC1 + VDAC1-ΔC and LGMN in T. Group B: low level of VDAC1 and absence of VDAC1-ΔC and LGMN. F, Expression of VDAC1-ΔC and Hsp-90 proteins was quantified in tumoral tissues (T) and VDAC1-ΔC/Hsp-90 ratio was obtained in each patient. G, Graphic representation of LGMN mRNA expression in patients from Group A compared to patients from Group B. H, HK2, RCC4+pVHL, RCC4, cell lysates were analyzed by immunoblotting for HIF-2α, HIF-1α, LGMN and VDAC1. β-tubulin and Hsp-90 were used as a loading control.