Figure 1.
Characterization of the C4-2 intracardiac systemic tumor model. (A) Experimental design. (B) In vivo bioluminescence imaging over time of an untreated mouse inoculated by intracardiac injection and 68Ga-PSMA-11 PET/CT at 7 weeks. (C) Bioluminescence radiance (photons/second/cm2/sr) as means of tumor burden of single organs ex vivo 7-9 weeks post-inoculation (mean ± SD, n=10 mice). (D) Liver disease burden was visible by eye, BLI, and H&E staining in all the control mice. (E) Lung metastases were only visible by BLI and H&E staining.