Figure 4.

RE nanoprobes for NIR bioimaging in vivo. (A). Principal scheme for in vivo experiments and NIR bioimaging. NIR images of mice at different localizations with different nanoparticle amounts. Adapted with permission from ⁸², Copyright 2007, National Academy of Sciences. (B). Schematic of the portable short-wave infrared (SWIR) imaging prototype using 980 nm NIR excitation and the bioimaging for injected tumor on nude mouse. Adapted with permission from ¹¹⁴, Copyright 2013, Nature Springer. (C) Scheme illustration of assembly and NIR laser‐regulated disassembly of nanoprobes for stable and accurate NIR‐II bioimaging. (D) Schematic depiction of experimental timeline for the in vivo assembly and 980 nm laser‐triggered in vivo disassembly and NIR‐II fluorescence bioimaging results for the abdomen (1000 nm long‐pass filter) of the nude mice with murine epidermal tumor by two‐staged in‐sequence injection of RE nanoparticles (interval between two injections is 10 h) under 808 nm excitation. Adapted with permission from ¹¹⁵, Copyright 2018, John Wiley & Sons, Inc.