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. 2020 Feb 3;11(8):2101–2112. doi: 10.7150/jca.37762

Figure 3.

Figure 3

CDH13 overexpression inhibited PC tumor progression in vivo. CDH13-overexpressing CFPAC-1 cells were orthotopically injected into the pancreas of nude mice. Cells transfected with the empty vector were used as a control. A, The orthotopic PC tumors removed at the time of euthanasia. B, Comparison of the pancreas weights with orthotopic tumors between the CDH13 overexpression group and control group. C-D, Representative macroscopic images of liver and mesenteric metastases in mice injected with control cells and CDH13-overexpressing CFPAC-1 cells. E, Animals with liver metastasis or mesentery metastasis were counted. F-G, H&E staining indicating the metastatic foci identified in the liver or mesentery of mice with orthotopic PC tumors (original magnification 100×). The data are presented as the mean ± SEM; n = 8 per group. ***P < 0.001 compared with the control group.