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. 2020 Feb 3;11(8):2158–2170. doi: 10.7150/jca.37255

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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B7-H3 promotes chemoresistance of CRC cells via STAT3/CDC25A. (A) The CRC cell proliferation rates upon silencing STAT3/CDC25A in control or B7-H3-overexpressing CRC cells were determined using the CCK8 assay and are presented as the mean ± SD of three independent experiments. (B) The effect of silencing STAT3/CDC25A on the colony formation assay in control or B7-H3-overexpressing CRC cells treated with 5 μM L-OHP for 2 h. (C) The LDH level upon silencing STAT3/CDC25A in control and B7-H3-overexpressing CRC cells were determined with the LDH assay and are presented as the mean ± SD of three independent experiments. **P<0.01, *P<0.05.