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. 2020 Feb 3;11(8):2222–2233. doi: 10.7150/jca.39679

Figure 5.

Figure 5

miR-5094 regulates T cells proliferation by targeting STAT5b. (A) Proliferation curves of CD4+CD25+ T cells from human Peripheral blood. (B) Proliferation curves of CD4+ T cells from human Peripheral blood. (C) Percentage of CD4+CD25+ T cells in CD4+ T cells at 72 h after radiation. (D) Expression of miR-5094 and STAT5b mRNA in CD4+ T cells at 24 h after radiation. U6 and GADPH mRNAs were used as controls. (E) Expression and activation of STAT5b in CD4+ T cells at 24 h after radiation. Cells were cultured with anti-CD3/CD28-coated beads (1:4) and subjected to IL-2 (20 U/mL) stimulation as indicated. NC: negative mock control; mcs: miR-5094 mimics; inhib: miR-5094 inhibitor; R: 2 Gy X-rays. *P < 0.05 and **P < 0.01 represent the comparison with NC.