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Mutations induce resistance to FGFR inhibitors
| FGFR | Mutated site | FGFR inhibitors |
|---|---|---|
| FGFR1 | V561M | PD173074, dovitinib, ponatinib, BGJ-398, E3810 |
| FGFR1 | N546K | PD173074, dovitinib, ponatinib, BGJ-398 |
| FGFR2 | V564F | BGJ-398 |
| FGFR2 | I567S | AZD4547 |
| FGFR2 | N568H/T | AZD4547 |
| FGFR2 | V581L | AZD4547 |
| FGFR2 | E584G | AZD4547 |
| FGFR2 | S587L | AZD4547 |
| FGFR2 | K600R | AZD4547 |
| FGFR2 | K678M | AZD4547 |
| FGFR3 | V555M | AZD4547, PD173074 |
