Table 3.
Signaling pathway induces resistance to FGFR inhibitors
| Cancer types | FGFR inhibitors | Involved signaling pathway |
|---|---|---|
| Lung cancer | BGJ398 | PI3K/AKT and GSK signaling pathway |
| Urothelial cancer | BGJ398 | PI3K/AKT and GSK signaling pathway |
| Urothelial cancer | AZD4547 | EGFR/ERBB3-AKT signaling pathway |
| Bladder cancer | PD173074 | EGFR signaling pathway |
| Endometrial cancer | Ponatinib | Loss of PTEN |
| Breast cancer | AZD4547 | MET, inactivation of RASA1, drug-efflux |
| Gastric cancer | AZD4547 | EMT |
| Gastric cancer | BGJ398 | EMT |
| Gastric cancer | PD173074 | EMT |