Table 5.

Univariate and multivariate survival analysis of PDAC patients

Factor	OS median (range)	Univariate analysis				Multivariate analysis
		HR	95%CI	P value		HR	95%CI	P value
Gender
Male	19.0(1.0-47.0)	1.054	0.555-2.004	0.871
Female	20.0(3.0-46.0)	1
Age
≥60	22.0(1.0-47.0)	0.677	0.365-1.254	0.215
<60	15.5(2.0-46.0)	1
T stage
T3	17.8(1.7-47.6)	1.778	0.822-3.845	0.144
≤T2	23.0(3.0-46.0)	1
N stage
N0	22.3(2.9-47.6)	1.279	0.694-2.357	0.431
N1	17.(1.7-45.8)	1
M stage
M0	18.4(1.7-47.6)	0.658	0.175-3.005	0.658
M1	23.2(12.4-40.3)	1
TMN stage
≥II	15.6(1.7-47.6)	3.052	1.087-8.567	0.034		2.899	1.731-4.855	<.0001
I	31.1(12.6-46.5)	1				1
Primary tumor location
Head and Neck	16.4(1.7-47.6)	1.204	0.657-2.209	0.548
Body and Tail	23.1(2.9-46.4)	1.000
Nerve invasion
Yes	13.6(1.7-46.5)	2.171	1.089-4.328	0.028		1.592	0.989-2.560	0.055
No	23.7(3.1-47.6)	1.000				1.000
Vascular invasion
Yes	7.9(3.1-46.5)	1.926	1.198-3.095	0.007		1.583	0.984-2.546	0.058
No	22.3(1.7-47.6)	1.000				1.000
Nuclear grade
III	12.1(1.7-44.6)	2.374	1.290-4.368	0.005		2.519	1.534-4.137	0.000
<II	23.2(4.0-47.6)	1.000				1.000
PKM2
Positive	12.5(1.7-46.5)	2.326	1.428-3.788	0.001		2.117	1.309-3.426	0.002
Negative	23.7(2.9-47.6)	1.000				1.000
CD206
Positive	9.4(1.7-46.5)	1.861	1.159-2.988	0.010		1.595	0.992-2.566	0.054
Negative	23.2(2.9-47.6)	1.000				1.000
PKM/CD206
PKM+/CD206+	7.3(1.7-46.5)	2.558	1.556-4.205	0.000		3.349	1.956-5.735	0.001
All others	23.1(2.9-47.6)	1.000				1.000