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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Neurobiol Dis. 2020 Jan 27;137:104783. doi: 10.1016/j.nbd.2020.104783

Table 1.

Top differentially expressed genes in 22L- and ME7-infected animals at the advanced stage of the disease.

mRNA 22L 3rd point Th ME7 3rd point Th Pathways
Log2 fold change std error (log2) P-value Log2 fold change std error (log2) P-value
Cxcl10 7.68 0.589 3.77E-07 7.73 0.589 3.55E-07 Astrocyte Function, Cytokine Signaling,
Inflammatory Signaling,
Innate Immune Response,
Microglia Function
Serpina3n 6.13 0.359 3.60E-08 5.54 0.359 8.81E-08 Astrocyte Function
Lag3 4.58 0.284 6.10E-08 3.98 0.285 2.09E-07
Fcgr2b 4.22 0.307 2.38E-07 3.87 0.307 4.99E-07 Adaptive Immune Response, Autophagy
C4a 4.05 0.243 4.56E-08 3.66 0.243 1.11E-07 Astrocyte Function
Slamf9 3.63 0.264 2.40E-07 3.1 0.266 9.87E-07 Microglia Function
C1qa 3.53 0.248 1.78E-07 3.22 0.248 3.95E-07 Innate Immune Response
Trem2 3.41 0.258 3.40E-07 3.03 0.259 9.41E-07 Adaptive Immune Response, Inflammatory Signaling,
Microglia Function
C1qb 3.29 0.23 1.74E-07 3.02 0.23 3.57E-07 Innate Immune Response
Tyrobp 3.27 0.268 6.62E-07 3.01 0.268 1.34E-06 Adaptive Immune Response,
Innate Immune Response
C1qc 3.21 0.237 2.73E-07 3 0.237 4.94E-07 Innate Immune Response
Fcrls 3 0.237 4.94E-07 2.84 0.237 7.81E-07 Microglia Function
Mpeg1 2.98 0.251 8.32E-07 2.86 0.251 1.21E-06 Inflammatory Signaling
Psmb8 2.87 0.232 5.99E-07 2.67 0.233 1.14E-06 Adaptive Immune Response, Angiogenesis,
Apoptosis,
Astrocyte Function, Cell Cycle,
Cytokine Signaling,
Growth Factor Signaling,
Inflammatory Signaling,
Insulin Signaling, Microglia Function,
NF-kB, Wnt
Ifi30 2.82 0.218 4.01E-07 2.5 0.22 1.21E-06 Adaptive Immune Response, Inflammatory Signaling
Stat1 2.18 0.147 1.22E-07 1.86 0.148 5.18E-07 Cytokine Signaling,
Growth Factor Signaling,
Inflammatory Signaling, Microglia Function
Olfml3 2.1 0.169 5.84E-07 2.23 0.169 3.32E-07 Matrix Remodeling