Figure 1.

Crmp4 deletion impairs the regeneration of sensory neurons following sciatic nerve injury. A, Maximal intensity projections of straightened Crmp4^+/+ or Crmp4 ^−/− sciatic nerves at 3 DPI following crush injury stained with SCG10, a marker of the regenerating sensory neurons. The injury site is labeled by a dotted line, and the extremity of the regenerating fibers is indicated by arrowheads. Scale bar, 500 μm. B, Quantification of the distance of regeneration of the SCG10⁺ sensory neurons at 3 DPI in Crmp4^+/+ and Crmp4^−/− mice. Data are represented as the mean number of neurons per square millimeter ± SEM. The difference between the genotypes is statistically significant (n = 5–6; two-way ANOVA, p = 0.0006).