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. 2020 Mar 2;19:26. doi: 10.1186/s12940-020-00580-3

Table 6.

The association between parabens and parameters of ovarian reserve- categorical variable

AFC AMH FSH E2
Categories coef 95%CI p coef 95%CI p coef 95%CI p coef 95%CI p
MP Cont. − 0.02 − 0.06;0.01 0.14 − 0.05 − 0.10;0.001 0.06 − 0.01 − 0.03;0.01 0.51 − 0.01 − 0.05;0.02 0.52
Q2 0.03 − 0.13;0.18 0.72 0.15 −0.09;0.40 0.22 0.05 − 0.05;0.15 0.34 0.03 − 0.15;0.20 0.76
Q3 −0.11 − 0.27;0.04 0.16 − 0.11 − 0.36;0.13 0.37 − 0.08 − 0.19;0.03 0.14 0.05 − 0.12;0.23 0.55
Q4 −0.05 − 0.21;0.11 0.54 −0.16 − 0.41;0.09 0.20 − 0.04 − 0.14;0.07 0.50 − 0.08 − 0.25;0.10 0.39
P for trend 0.52 0.21 0.50 0.40
EP Cont. −0.004 − 0.03;0.02 0.77 − 0.03 − 0.07;0.02 0.22 0.002 − 0.02;0.02 0.81 − 0.03 − 0.06;0.05 0.09
Q2 −0.01 −0.17;0.15 0.95 −0.15 − 0.41;0.10 0.24 − 0.09 −0.20;0.02 0.12 0.04 −0.14;0.22 0.66
Q3 0.03 −0.13;0.18 0.76 0.02 −0.23;0.26 0.91 0.01 −0.09;0.12 0.79 −0.01 −0.24;0.11 0.45
Q4 −0.02 −0.18;0.14 0.83 −0.18 − 0.43;0.07 0.16 − 0.05 −0.15;0.06 0.39 −0.14 − 0.32;0.04 0.12
P for trend 0.84 0.20 0.39 0.29
PP Cont. −0.02 −0.13;-0.01 0.04 −0.03 −0.07;0.02 0.22 0.03 0.02;0.12 0.028 −0.03 −0.06;-0.001 0.04
Q2 −0.06 −0.22;0.04 0.14 −0.09 − 0.35;0.16 0.49 0.02 −0.08;0.01 0.09 −0.12 − 0.29;0.05 0.18
Q3 −0.03 −0.20;-0.02 0.048 −0.01 − 0.3;0.25 0.96 0.05 0.03;0.18 0.026 −0.11 −0.20;-0.01 0.03
Q4 −0.03 −0.18;-0.03 0.05 −0.08 − 0.33;0.17 0.54 0.02 −0.08;0.03 0.07 −0.13 − 0.31;0.04 0.13
P for trend 0.04 0.36 0.03 0.04
iBuP Cont. 0.02 −0.05;0.09 0.61 −0.003 −0.11;0.10 0.95 −0.02 − 0.07;0.02 0.31 − 0.02 −0.10;0.06 0.62
>LOD 0.1 −0.07;0.27 0.24 0.03 −0.24;0.30 0.84 −0.01 −0.11;0.10 0.96 −0.13 − 0.31;0.04 0.14
BP Cont. 0.004 −0.04;0.05 0.84 −0.05 −0.12;0.01 0.11 −0.01 − 0.04;0.02 0.49 0.005 −0.04;0.05 0.83
Q2 −0.04 −0.19;0.12 0.64 −0.02 − 0.26;0.22 0.87 − 0.03 −0.13;0.07 0.58 −0.13 − 0.30;0.04 0.14
Q3 0.07 −0.08;0.22 0.35 0.02 −0.23;0.26 0.89 −0.09 −0.19;0.01 0.08 0.05 −0.12;0.22 0.56
Q4 0.01 −0.14;0.16 0.89 −0.20 −0.45;0.04 0.11 −0.01 − 0.11;0.10 0.90 − 0.08 −0.25;0.09 0.37
P for trend 0.89 0.12 0.90 0.36

Model adjusted for: age (years), BMI (kg/m2), smoking (Yes/No) and initial infertility diagnosis. Parabens exposure in the model was based on the first urine sample

MP methyl-paraben, EP ethyl-paraben, PP propyl-paraben, BP butyl-paraben, iBuP izobuthyl-paraben

Reference groups 1. In case >LOD reference is <LOD; 2. In case Q2, Q3, Q4 reference is Q1; Cont.-continuous variable

Q1- ≤ 25 percentyl; Q2- (25–50] percentyl; Q3-(50–75] percentyl; Q4- > 75 percentyl