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. 2020 Mar 2;19:50. doi: 10.1186/s12943-020-01169-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Gemcitabine resistance and metabolism. Gemcitabine and some intrinsic characteristics of pancreatic cancer cells produce chemoresistance. Ovals are biological substances, rectangles are processes, and hexagons are statuses. Red names indicate corresponding inhibitors. Arrows represent positive regulations, and lines with blunt ends represent negative regulations. CR, chemoresistance; EMT, epithelial-mesenchymal transition; FBP1, fructose-1,6-bisphosphatase 1; IDH1, isocitrate dehydrogenase 1; LAT2, L-type amino acid transporter 2; noPPP, nonoxidative pentose phosphate pathway; RRM2, ribonucleotide reductase subunit-M2