Table 1.
Results of the faecal egg count reduction (FECR) after treatment with different doses of albendazole and the 50% effective concentration (EC50) in the egg hatch test for goats naturally infected with gastrointestinal nematodes or experimentally infected with local Haemonchus contortus isolates at Rehed Al-Birdi, Tulus and Um Dafuq (South Darfur, Sudan)
| Study area | Infection type | GI nematodes | Dose (mg/kg bw) | No. of animals in each trial | Day 8 | Day 14 | EC50 (µg/ml thiabendazole) | ||
|---|---|---|---|---|---|---|---|---|---|
| FECR (%) Unpaireda |
FECR (%) Paireda |
FECR (%) Unpaireda |
FECR (%) Paireda |
||||||
| Rehed Al-Birdi | Natural | Strongyles | 5 | C: n = 8 | 93.3 (82.1–97.7) | 94.1 (92.4–95.6) | 87.5 (68.5–94.9) | 90.2 (88.3–91.8) | 0.08 (0.03–0.24) |
| T: n = 8 | |||||||||
| Strongyles | 7.5 | C: n = 13 | 92.1 (80.5–96.6) | 95.6 (94.8–96.3) | 87.1 (72.8–94.4) | 93.7 (92.9–94.5) | |||
| T: n = 10 | |||||||||
| Strongyles | 10 | C: n = 13 | 90.4 (82–95.2) | 92.2 (91.5–93) | 86.5 (71.8–93.1) | 89.8 (88.9–90.7) | |||
| T: n = 25 | |||||||||
| Strongyles | 12.5 | C: n = 13 | 97.1 (93.4–98.8) | 97.5 (96.7–98) | 96.6 (89.9–98.8) | 97.2 (96.4–97.8) | |||
| T: n = 13 | |||||||||
| Tulus | Natural | Strongyles | 5 | C: n = 11 | 92 (86.1–95.2) | 94.6 (94.1–95) | 85.8 (72.1–93.4) | 88.5 (87.8–89.1) | 0.08 (0.07–0.1) |
| T: n = 27 | |||||||||
| 5 | Rb: n = 12 | na | 64.5 (60.2–68.4) | na | 54.4 (49.8–59.4) | ||||
| 10 | C: n = 11 | 89.9 (76.1–95.2) | 90 (88.7–91.2) | 89.6 (65.5–96.2) | 87.3 (85.8–88.7) | ||||
| T: n = 12 | |||||||||
| Experi-mental | H. contortus | 5 | C: n = 8 | 85.2 (60.1–93.5) | 86.2 (84.7–87.5) | 76.3 (34.1–91.9) | 81.8 (79.9–83.4) | 0.11 (0.08–0.16) | |
| T: n = 8 | |||||||||
| Um Dafuq | Experi-mental | H. contortus | 5 | C: n = 8 | 90.9 (80.2–94.8) | 84.2 (82.9–85.5) | 82.8 (57–90.8) | 73.5 (72–75.4) | 0.11 (0.07–0.17) |
| T: n = 8 | |||||||||
aFECRs were calculated either by comparing data post-treatment between treatment and control group (unpaired) or between data post- and pre-treatment (paired); 95% confidence interval is provided in parentheses
bRetreated goats were initially treated first with 5 mg/kg albendazole and received a repeated dose of albendazole (5 mg/kg body weight) on day 14
Abbreviations: bw, body weight; C, control; T, treated; R, retreated; na, no control group available since the treated group was retreated for the second time