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(A) FcRn binds to Fc-Ivermectin-NPs in an acidic environment, NPs transcytose across the epithelial-cell barrier and get release at physiological pH of blood. (B) Synthetic strategy of PLGA-b-PEG-Mal. (C) GPC traces of the polymers. (D) Synthesis of IVM loaded NPs using nanoprecipitation. (E) Incorporation of targeting antibody Fc on the NPs.
