Table 1.
Condition | Drug Dosage | % Symptom Reduction | % Adverse Effects | Study Size | Citation |
---|---|---|---|---|---|
Lennox-Gastaut Syndrome | 20 mg/kg/day, titrated over 11 days | 43.9% | 86% | n = 156 | Thiele et al., 2018 |
Dravet Syndrome | 20 mg/kg/day, titrated over 11 days | 43% | 93% | n = 108 | Devinsky et al., 2017 |
Parkinson’s Disease | 20 mg/kg/day, titrated by 2.5–5 mg/kg at 3–5 day intervals | NA | 100% | n = 13 | Leehey, 2019 |
Ulcerative Colitis | 50–200 mg/day | 28% | 96.6% | n = 60 | Irving et al., 2018 |
Cannabis Use Disorder | Up to 800 mg/day | 0% | NA | n = 4 | Hill, 2016 |
Opioid Use Disorder | 400 mg/day or 800 mg/day | 100% | 66.7% | n = 10 | Gonzalez-Cuevas et al., 2018 |
Cognitive Dysfunction | 600 mg/day | 0% | 71.4% | n = 36 | Boggs et al., 2018 |
Clinical trial results from Epidiolex-focused studies: The table summarizes the results from the currently completed clinical trials that have tested Epidiolex’s efficacy against various conditions. The % symptom reduction is reported as the percentage of patients in the treatment group to report improvement in the treatment of their condition. Similarly, the % of adverse effects refers to the total percentage of treatment group patients that reported any adverse effect. The sample size describes the number of patients that have completed the clinical trial currently.