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. 2020 Feb 10;10(7):3325–3339. doi: 10.7150/thno.41228

Figure 6.

Figure 6

Biosafety estimation of various formulations. (A) Cytotoxicity of empty NPs and empty NPs@HeLa against HeLa cells after 72 h treatment with different concentrations. (B) Effects of different formulations on body weight of HeLa subcutaneous xenograft mice. (C) Test results of white blood cells count, plasma ALT, and AST at the end of treatment. (D) Representative H&E staining histological images of major organs from mice receiving different treatment. Scale bar, 60 µm. The arrow points to liver necrosis. Data are given as the mean ± SD (n = 5 mice per group). *p < 0.05, NS indicates p > 0.05.